Many people have been asking how I prepared for Step 1. Sorry for the delay in responding. The most important thing I want to say is that you should have a target score in mind. For me, my target was to get above the national mean. Although I’m British and I was educated in the U.K. for most of my life, I attend an American medical school so I’m very familiar with what’s required on either side of the pond. Disclaimer: this is only my opinion. I have no inside secrets and I am most definitely not going to reconstruct Step 1 questions from memory. With respect for the test writers, please don’t ask me to do this. For Step 1, the best advice I can give medical students is to work hard while you are in medical school. Step 1 does not ask ‘what’, it asks ‘why’. It is not really a test that rewards the best of memorisers (and I’m not one of them). It is an exam that requires understanding. It covers a LOT of information, but it’s not impossible to pass if you prepare diligently and take enough time to relax. You are expected to know the pathophysiological mechanisms behind all of the major diseases, and often they are merely implied in the question stem. There are few ‘knee-jerk’ prompts in the questions stem, and often you will have nothing more than symptoms, laboratory data, and a peripheral blood smear to pick up on a disease like hereditary elliptocytosis (something similar turned up on my exam). Keep in mind that what worked for me might not work for you. I studied for four weeks, and I studied around eight hours per day. Some days, I was less productive. Overall, I was relaxed and I did not kill myself. I consider myself to be an average medical student. These are the resources that I found to be most useful, in my humble opinion: 1. First Aid for Step 1. If you know this book cold, you’ll be fine. It contains all of the high-yield information on Step 1. Beware: it is VERY abbreviated and, by itself, it is useless and nonsensical. My strategy was to make my own extended notes in the margin while I was taking some of the heavily-tested subjects on Step 1 in medical school (pathology, pharmacology, immunology etc.). By the time I came to prepare for Step 1, FA was quite complete, and I just referred to it when I had time, and I spent the last three days memorising as much minutia as I possibly could before Step 1. 2. Robbins Review of Pathology Question book. These questions are VERY hard, and quite involved. I would say that they are a little harder than what Step 1 expects of you, but the question length and the second- and third-order thinking needed to do well on Step 1 is pretty similar. Pathology and pathophysiology are without doubt the most heavily-tested entities on Step 1. This is high-yield. 3. BRS pathology. An excellent book that I used alongside my medical school pathology course. The questions are easier than what you’ll see on Step 1, but it has everything there and it’s more complete than First Aid. 4. BRS physiology. This is an excellent summary of all of the major mechanisms that turn up on Step 1. Step 1 physiology questions are often integrated with pathology, and my own experience was a whirlwind of “up/down” arrow questions for endocrinology and acid-base balance. I would know those cold. In addition, Step 1 will expect you to interpret all of the pulmonary and cardiovascular graphs rapidly (volume-pressure loops, wigger diagram, murmurs, FEV1 curves, flow in the circulation etc,) so this is worth knowing well. You also need to know all of the major calculations in cardiovascular, renal, and pulmonary physiology, and pharmacokinetics for pharmacology. 5. Medical Microbiology Made Ridiculously Simple. I read this book slowly, and found it to be high-yield. My own Step 1 exam required one to know all of the lab tests that you’d use for common bacteria and viruses as well as which viruses are single-stranded, naked etc. Often, this is implied in the question stem – the symptoms of a virus are given, and you will be expected to identify the virus in the options by knowing if it’s made of DNA or RNA, single-stranded, naked or enveloped etc. Parasites and fungi are lower yield, but fair game. Often microbiology is integrated with pharmacology: they might show you a picture of neisseria gonorrhea, describe some symptoms, and expect you to pick out that ceftriaxone is the best outpatient drug of choice in the first instance. 6. Kaplan Pharmacology Lecture Notes. I can’t say enough about this book. It gives you exactly what you need to know for Step 1. It is also high yield. You are held accountable for all of the major drugs and side effects, and the post-receptor signal transduction pathways (I had around 10 of those questions on my own exam). 7. Kaplan biochemistry and Genetics Lecture Notes. This is detailed, but it is excellent. You MUST know all of the major enzymes and rate-limiting steps involved in inborn errors of metabolism. You MUST know all of the rate-determining steps in glycolysis, the TCA cycle, the electron transport system (including all of the shuttles), fatty acid biosynthesis, beta oxidation, the pentose phosphate shunt pathway, the Cori Cycle, the Urea Cycle etc. I had several vitamin questions that required you to know which biochemical enzymes use them, and what the symptoms would be. There were several molecular questions on my test, but I honestly felt that any reasonably-bright medical student would be able to work them out right there – PCR, interpreting paternity DNA digests, Southern blots, Westerns, and knowing the nuts and bolts of immunoassays, fluorescent immunostains, and FACS analysis. Hardy-Weinberg calculations are fair game, and you must know all of the major diseases and their mode of inheritance (autosomal, x-linked, mitochondrial, dominant, recessive, and how this changed with penetrance and mosaicism etc.) 8: Kaplan Anatomy and Embryology Lecture Notes. Most of the anatomy is integrated with pathology. They might describe a knife fight and the presentation of a patient to the ER and, from the description of the laceration, you'll need to know which lobe of which lung or which chamber of the heart is punctured, and at which vertebral level this can be found. I had a ton of MRIs and CTs (especially of the head) on my exam, and I found the neuro section of this book to be excellent. You MUST know all of the major nuclei at every level of the brain stem and spinal cord, and know the major lesions and symptoms - including the odd ones like ALS, MS, syringomyelia etc. You also need to know all of the major nerve tracts in the spinal cord and all of the cranial nerve signs cold. I make no bones about this. It's important and it's very high yield. The First Aid book is totally useless for anatomy, in my opinion. Brachial plexus is very high yield. I had three questions on my exam that required you to know the plexus by heart and identify a nerve root from a diagram, and localise motor and sensory lesions from symptoms. For embryology, the pharyngeal pouches are high yield - as are gut and cardiac malformations. I hated anatomy and embryology in medical school because I loathe memorisation for the sake memorisation, though I found that simply doing questions was enough to make me presentable - other than for neuro which, again, is very high yield. 9. Kaplan Q bank. I got through around 80% of this, but honestly felt that the questions were too esoteric and not reflective of what’s on Step 1 at all. This is a little outdated. However, the long questions and question choices (anything from A-to-D to A-to-K! That’s right) are fair game on Step 1. That was a shocker for me. I expected all of the Step 1 questions to be A-to-E. Several were, but anything is possible. Kaplan’s explanations are a little outdated, but it will get you to where you need to be. DO NOT WORRY ABOUT YOUR SCORE. FOCUS ON LEARNING. I always did these questions in the mixed, timed, and unused mode. 10. USMLEWORLD. I felt that the second- and third-order questions on here were very similar to the thought process needed to do well on Step 1. There are many subtleties in the question stem that you must pick up on to get the right answer. In addition, the explanations here are superior to Kaplan, in my opinion. However, the question stems are FAR too short and do not reflect Step 1 at all. This led me into a false sense of security. There were also a lot of annoying typos in there, making me question the QC of this company. The computer interface on this question bank is identical to Step 1 and this may get USMLEWORLD in trouble sooner or later; I did not think the latter feature conferred a significant advantage. I got through around 90% of USMLEWORLD, and I was pleased with my purchase. DO NOT WORRY ABOUT YOUR SCORE. FOCUS ON LEARNING. I always did these questions in the mixed, timed, and unused mode. In the last 2 weeks, I did around 150 questions per day in 50 question blocks, and went over the answers. I wrote down anything that surprised me. In my opinion, making detailed paper notes for everything is not a valuable use of time. Towards the ends, I did around 300 questions per day to build up my stamina for Step 1. I hope that helps. Good luck to whomever is reading this!